Research and Innovation

Nuvance Health™ conducts groundbreaking research and innovation to improve patient care and advance the field of medicine.

At Nuvance Health, research and innovation are a top priority—unlocking advancements that improve health care now and in the future.

Rudy L. Ruggles Biomedical Research Institute

Renowned scientists perform translational research, which uses scientific findings to improve the standard of patient care and advance our community’s health. Discover more about this groundbreaking work and expertise.

Rudy L. Ruggles Biomedical Research Institute
Research - African American Scientist

Clinical Trials

Nuvance Health serves as a research site for many national and international clinical trials. Learn how these studies evaluate new approaches to prevent, diagnose and treat disease.

View Open Trials
Researcher grabs test tube

Lyme Disease Research and Prevention

Researchers educate the public about Lyme disease prevention, developing new diagnostic methods and collaborating on biobanking efforts.

Lyme Disease Research and Prevention
test tubes with lyme disease label

Research and Innovation at Nuvance Health

At Nuvance Health, research and innovation are a top priority—unlocking advancements that improve health care now and in the future. Highlights of the program include:

  • A full range of research initiatives:
    Offerings include translational, clinical and investigator-led research. This robust program is on par with that of major academic medical centers in our region and beyond.
  • Strong research pipeline:
    Sponsors and partner institutions seek out Nuvance Health based on our reputation for solid research. This broad network creates a strong pipeline of opportunities for eligible patients to participate in research.
  • Access to new treatments:
    We provide avenues for patients to be involved in important studies and trials close to home. Eligible patients may have access to promising new therapies before they’re widely available.
  • Career and educational opportunities:
    Nuvance Health offers a launchpad for a rewarding career. We also train the next generation of clinicians and researchers, through internships and fellowships, to make important discoveries.

Clinical Trial Listings

  • Alzheimer's

    Evoke Plus
    A randomized double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)

    A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ)

  • Arrhythmia

    Assessment of Primary Prevention Patients Receiving an Implanted Cardiac Defibrillator – Systematic Evaluation of ATP
    Adapt Response
    The purpose of this clinical study is to test the hypothesis that market released Cardiac Resynchronization Therapy (CRT) devices which contain the AdaptivCRT® (aCRT) algorithm have a superior outcome compared to standard CRT devices in CRT indicated patients with normal atrio-ventricular (AV) conduction and left bundle branch block (LBBB).
    Brady MRI
    The purpose of this post approval study is to evaluate the long-term safety of the FDA approved St. Jude Medical Tendril MRI™ lead implanted with a SJM Brady MRI implantable pulse generator (IPG) such as the Accent MRI™, Assurity MRI™, Endurity MRI™ pacemaker, or similar model (SJM Brady MRI System) in subjects with a standard bradycardia pacing indication.
    A multicenter, Randomized, Active-control study to evaluate the safety and tolerability of two blinded doses of Abenacimab compared with open label rivaroxaban in patients with Atrial Fibrillation
    Product Surveillance Registry Platform
    Evaluate the periodic reporting of safety and effectiveness of Medtronic market-relased products for their intended use

  • Cervical Hyperplasia

    Reveal 2
    Randomized Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL

  • Cognitive Impairment

    Long-Term Nicotine Treatment of Mild Cognitive Impairment

  • Coronary Disease

    A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Effects of Bempedoic Acid (ETC-1002) on the Occurrence of Major Cardiovascular Events in Patients wiith, or at High Risk for, Cardiovascular Disease Who are Statin Intolerant.

    Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting Stents

    HP-4/TIMI 65/ORION 4
    A double-blind, randomized, placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease.

    Vesalius CV
    A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infactrion or Stroke

  • COVID-19

    A Phase III Randomized, Double-blind, Placebo-controlled Multicenter Study in Adults to Determine the Safety, Efficacy, and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, for the Prevention of COVID-19
    ACTIV 5/Big Effect Trial (BET-A/BET-B)

    A Multicenter Platform Trial of Putative Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
  • Crohn's Disease

    A Phase 3, Multicenter, Randomized, Efficacy Assessor-Blinded Study of Risankizumab Compared to Ustekinumab for the Treatment of Adult Subjects with Moderate to Severe Crohn's Disease Who Have Failed Anti-TNF Therapy

  • Eosinophilic Esophagitis

    Efficacy and Safety APT-1011 in Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2) (FLUTE-2)

  • Giant Cell Arteritis

    A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Giant cell Arteritis

  • Heart Failure


    A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Injectafer® (Ferric Carboxymaltose) as Treatment for Heart Failure with Iron Deficiency 

    Paraglide HF

    A multicenter, randomized, double-blind, double-dummy, parallel group, active controlled study to evaluate the effect of sacubitril/valsartan (LCZ696) vs. valsartan on changes in NT-proBNP and outcomes, safety and tolerability in HFpEF patients with acute decompensated heart failure (ADHF) who have ben stabilized during hospitalization and initiated in-hospital or within 30 days post discharge.


    The GUIDE-HF IDE clinical trial is intended to demonstrate the effectiveness of the CardioMEMS™ HF System in an expanded patient population including heart failure (HF) patients outside of the present indication, but at risk for future HF events or mortality.


    A multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of finerenone on morbidity and mortality in participants with heart failure (NYHA II-IV) and left ventricular ejection fraction >40%.


    Randomized Clinical Evaluation of the AccuCinch Ventricular Restoration System in Patients who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF).


    This is an international, multicenter, parallel-group, randomized, double-blind, placebo-controlled trial in patients with heart failure with reduced ejection fraction (left ventricular ejection fraction [LVEF] ≤40%) who have been stabilized during hospitalization for acute heart failure, evaluating the effect of in-hospital initiation of dapagliflozin versus placebo on the clinical outcome of cardiovascular death or worsening heart failure

  • Lupus

    A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without Benlysta (belimumab)

  • Migraine

    Post-Authorization Safety Study Protocol (PASS)

    A Long-Term, Prospective, Observational Study to Evaluate the Safety, Including Cardiovascular Safety, of Fremanezumab in Patients with Migraine in Routine Clinical Practice. 

    Nerivio TCH-008

    A prospective, randomized, double-blind, sham-controlled multi-center clinical study assessing the safety and efficacy of Nerivio for the preventive treatment of migraine

    AMG 334 Erenumab

    Phase 4 Open Label study to evaluate treatment satisfaction with Erenumab in patients with Migraine

  • Multiple Sclerosis

    An Observational Study of Ocrelizumab-Treated Patients with Multiple Sclerosis to Determine the Incidence and Mortality Rates of Breast Cancer and All Malignancies

  • Myocardial Infarction

    A multicenter, randomized, double-blind, active-controlled study to evaluate the effects of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction
    North American COVID-19 ST-Segment Elevation Myocardial Infarction (NACMI) Registry
    A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome

  • Parkinson's Disease


    A Double-Blind, Placebo-controlled, Randomized, 18-month Phase 2A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral UCB0599 In Study Participants with Early Parkinson's Disease

  • Pulmonary
    Losartan Effects on Emphysema Progression

    A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States.

  • Stroke

    Anticoagulation in ICH Survivors for Stroke Prevention and Recovery (ASPIRE)

  • Valvular

    Optimize PRO
    Optimize PRO TAVR Post Market Study

    Proact XA
    A prospective, randomized, active (warfarin) controlled, parallel-arm clinical trial to determine if patients with a ON-X aortic valve can be maintained safely and effectively on the factor XA inhibitor apixaban

  • Vascular

    A Study of Patients with Lower Extremity Acute Limb Ischemia to Remove Thrombus with the Indigo® Aspiration System