Courtney holds a B.A. in Forensic Science with a concentration in biology from the University of New Haven. As a biobank research assistant, she attends surgeries to collect patient samples and processes blood, lavage, and tissue samples for biobank storage and inventory.
We’re committed to personalized medicine that improves our ability to diagnose and treat disease.
The biorepository is critical to research programs at Rudy L. Ruggles Biomedical Research Institute and clinical trials that require access to patient specimens. The Nuvance Health biobank contains specimens from consenting patients such as:
- Patient-derived tissue
- Blood, plasma or serum
- Cell lines
Specimens are accompanied by detailed data linked to personal, clinical and genomic information. The ability to generate and analyze this data from samples and cells preserved in their natural state aids our understanding, prevention, diagnosis, treatment of complex diseases. Nuvance Health’s biorepository has in place an IRB-approved, HIPAA complaint protocol for biobanking. We also have a lab-based framework to allow for the enrollment of patients and the collection, processing and storage of samples.
The biobank has evolved to accommodate our needs for advanced research in translational medicine. This medicine is geared towards molecular analysis of disease and targeted therapies to improve clinical outcomes.
We collect a range of cellular and tissue samples at various stages. These samples include:
- Tissue that has been microdissected into cell subpopulations (tumor and surrounding benign tissue and lymph node sections)
- Microenvironment biopsies
- Benign tissue with associated germline tissue/peripheral blood mononuclear cells (PBMC)
- Plasma samples enriched for circulating tumor cells
- Circulation DNA
- Rare cells
- Tumor DNA from cancer patients
Biobanking benefits the research at Nuvance Health by potentially leading to:
- New biomarkers for early diagnosis and prognosis of disease to help guide treatment
- Discovery and in vivo and in vitro testing of novel drugs and treatments that are less toxic and target cancer cells while sparing healthy tissue
- More effective personalized drugs based on an individual’s DNA and other information
- New diagnostic techniques to identify people who are at risk or who are likely to benefit from certain treatments
The biorepository currently stores a range of cancer samples, including:
- Endometrial cancer samples
- Ovarian cancer samples
- Fallopian and ovarian cancer samples
- Cervical cancer samples
- Uterine cancer samples
- Vulvar cancer samples
- Benign samples
- Pancreatic cancer samples
Its components are:
The biobank’s incubators, freezers and refrigerator have backup generator power and a local on-site alarm. The equipment also has a robust, off-site 24/7 alarm system that monitors fluctuating temperatures. Other equipment includes tissue and cell dissociators, microscopes, PCR (real-time, digital and droplet digital) machines, centrifuges, spectrophotometers, gel-running apparatus and an imaging and analysis workstation for nuclear and protein analysis. The biobank employs two full-time research assistants who obtain, process and manage the inventory of its biological samples.